![]() In fact, they are all based on semen analysis according to 1999 WHO criteria, and ovarian hyperstimulation aiming for two or three dominant follicles at ovulation induction (OI) prior to IUI. As IUI is a relatively simple procedure associated with far lower risks and potential complications, and costs than IVF, it would be clinically useful to predict which patients have a high chance of pregnancy with IUI.Īlthough models predicting pregnancy after IUI have been previously published, they are not widely used in clinical routine practice. Nonetheless, in women with unexplained infertility < 38 years, comparable live birth rates after ovarian stimulation with IUI and IVF have been reported. In contrast, based on a multi-center retrospective analysis from 22 European centers evaluating more than 175,000 IUIs, IUI achieved a pregnancy rate of only 8.6% per cycle, albeit with large variability between centers ranging from 4 to 13%. Today, due to increasing per cycle success rates of over 30% in achieving pregnancy through in vitro fertilization (IVF), many couples choose this option as an initial treatment. Homologous intrauterine insemination (IUI) with or without ovarian stimulation has historically been used as first-line treatment for infertility. A simple to use score could be used to estimate a couple’s chance of achieving pregnancy via IUI, facilitating individualized counseling and decision-making. IUI success rates vary widely depending on couples’ characteristics. In contrast, couples with a score of 0 had a cumulative probability of only 5%. Following 3 cycles, couples in our cohort with a score of 5 had a cumulative probability of achieving pregnancy of nearly 45%. We developed a predictive clinical score ranging from 0 to 5. We found a per cycle pregnancy rate of 10.9% and a cumulative pregnancy rate of 19.4%. Overall, 1437 IUI cycles in 758 couples were evaluated. ![]() ![]() Predictive factors for pregnancy after IUI were identified, and a predictive score was developed using a multivariable continuation ratio model. The primary outcome measure was pregnancy, defined as positive serum human chorionic gonadotropin (hCG) 12–14 days after IUI. We performed a retrospective cohort study evaluating the homologous IUI cycles performed at a single university-based reproductive medical center between 20. To develop a predictive score for the success of intrauterine insemination (IUI) based on clinical parameters.
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